反应详情

In 4 liters of ethanol was suspended 48.94 g of 7-hydroxy-2-hydroxymethyl-5-methoxycarbonyl-s-triazolo[1,5-a]pyrimidine, and 33 g of sodium borohydride was added little by little thereto and then the mixture was stirred at room temperature for 3 hours and then refluxed for 4 hours. A residue obtained by removing ethanol was dissolved in 2 liters of water, and 500 ml of Amberlite IRC-50 (H+) (trade name) was added thereto and stirred. Subsequently, the mixture was filtered and after removing water from the filtrate, 500 ml of methanol was added to the filtrate and the mixture was stirred. Then, methanol was removed from the mixture to obtain a residue. These procedures were repeated three times. Then, 500 ml of ethanol was added to the residue and the mixture was condensed. Precipitated crystal was collected by filtration, washed with ethanol and dried to obtain 39.35 g of the title compound.

1. additionwas added little by little thereto and then the mixture
2. temperaturerefluxed for 4 hours
3. customA residue obtained
4. customby removing ethanol
5. dissolutionwas dissolved in 2 liters of water
6. addition500 ml of Amberlite IRC-50 (H+) (trade name) was added
7. stirringstirred
8. filtrationSubsequently, the mixture was filtered
9. customafter removing water from the filtrate, 500 ml of methanol
10. additionwas added to the filtrate
11. stirringthe mixture was stirred
12. customThen, methanol was removed from the mixture
13. customto obtain a residue
14. customcondensed
15. customPrecipitated crystal
16. filtrationwas collected by filtration
17. washwashed with ethanol
18. customdried