Diethyl Ether → HCID 14851228, compound

Participants

Reaction Steps

To 7.26 g (0.02 mole) of the ethyl 2-bromo-3-(2-methoxyethoxy)-4ethylsulfonylbenzoate in 50 mL of 80% methanol/water was added 1.2 g (0.03 mole) of sodium hydroxide. After stirring at room temperature overnight, 100 mL of ether was added and the organic phase was extracted three times with 50 mL of 1 N NaOH. The combined base extracts were acidified and extracted three times with methylene chloride. The methylene chloride was dried and concentrated to yield 6.6 grams of 2-bromo-3-(2-methoxyethoxy)-4-ethylsulfonylbenzoic acid as a viscous oil.

Provenance & Evidence