L-Valine → HCID 131716562, compound

Participants

Reaction Steps

Benzhydrylamine-resin (BHA) (5.0 g, 0.5-0.7 meg/g) was coupled with Boc-Val-OH (3.04 g, 14 mmol) in CH2Cl2 (25 mL) with dicyclohexylcarbodiimide (DCC) (2.88 g) for 18 hrs. The resultant BOC-Val-BHA-resin was washed with CH2Cl2 (2×75 mL), DMF (1×75 mL), MeOH (2×75 mL), CH2Cl2 (2×75 mL) and dried. An aliquot was hydrolyzed (1 mL of 6M propionic-HCl at 130° for 2 hours). Amino acid analysis showed a substitution of 0.33 mmol of Val per gram of resin. The remaining amino groups were acetylated with AC2O-pyridine, yield: 5.36 g.

Provenance & Evidence