Water → HCID 14822622, compound

Participants

Reaction Steps

1-[N-methyl-N-(2,2-dimethoxyethyl)aminocarbonyl]-6-methoxy-indane 3.5 g (12 mmol), an amidoacetal compound of Formula 5, was dissolved in 20 ml of ether and added to 1.0 g (26 mmol) of LAH in 100 ml of ether. The reaction mixture was stirred at ambient temperature for 48 hours and then treated dropwise with 1 ml of water, 1 ml of 15% NaOH, and finally 3 ml of water. The insoluble inorganic materials were removed by filtration and the filtrate was concentrated to give the 3.1 g of 1-[N-methyl-N-(2,2-dimethoxyethyl)aminomethyl]-6-methoxy-indane, an aminoacetal of Formula 6, which is used without further purification.

Provenance & Evidence