Water → HCID 70374317, compound

Participants

Reaction Steps

A sample of 550 mg (2.7 mmol) of 1-oxo-2-methyl-5-methoxy-1,3,4,8,9,9a-hexahydro-2H-indeno[1,7-cd]azepine, a compound of Formula 10 prepared, for example, as described in Preparation 10A, was dissolved in 100 ml of diethylether followed by the addition of 750 mg (19 mmol) of LAH. The reaction was allowed to proceed for 24 hours at ambient temperature. The reaction mixture is treated dropwise with about 1 ml of water, 1 ml of 15% NaOH, and then 3 ml of water. Insoluble inorganic materials are removed by filtration and the filtrate concentrated to give 2-methyl-5-methoxy-1,3,4,8,9,9a-hexahydro-2H-indeno[1,7-cd]azepine, a compound of Formula I, as the free base; (HBr salt, mp 250°-252° C.).

Provenance & Evidence