Acetic Anhydride → HCID 21639731, compound

Participants

Reaction Steps

Reacting 1-N-acetyl-20-(-N',N'-dimethyl)decyl diamine (prepare from 1,10-(-N',N'-dimethyl)decyl diamine with acetyl chloride) with lithium diisopropylamide, followed by 5-triethylsilyl-3-furaldehyde and acetic anhydride gives 4-[1-acetoxy-2(N-10-N',N'-dimethyl)aminodecyl)amido]ethyl-2-trimethylsilylfuran. Treatment of this intermediate with excess iodomethane followed by singlet oxygen oxidation gives r-[1-acetoxy-2-(N-10-(N',N',N'-trimethyl)aminodecyl)amido]ethyl-5-hydroxy-2(5H)-furanone.

Provenance & Evidence