HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylamide → 8-chloro-1,4,5,6-tetrahydrobenzo[f]quinolin-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylamide | HCID 6579 | — |
| Reactant | Pyrrolidine, 1-(6-chloro-3,4-dihydro-2-naphthalenyl)- | HCID 10444008 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-chloro-1,4,5,6-tetrahydrobenzo[f]quinolin-3(2H)-one | HCID 10466539 | — |
Reaction Steps
701 g (3 mol) of 1-(6-chloro-3,4-dihydro-2-naphthyl)pyrrolidine and 640 g (19 mol) of acrylamide in 7 ml of ethanol were boiled under reflux for 3 days with the addition of 70 g of Amberlite IR200. The separated solid was filtered off. Extractive crystallization with dioxan gave 8-chloro-1,4,5,6-tetrahydrobenzo[f]-quinolin-3(2H)-one of melting point 228°-230° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04957911 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-80a7ec1bab91491b99d7e77a4e8e5218 |
| Source note | uspto-grants-1990_09 |