Chlorotrimethylsilane → Dimethyl 3,3'-(((3-formylphenyl)methylene)bis(sulfanediyl))dipropanoate

Participants

Reaction Steps

To a solution of isophthalaldehyde (5.4 g) in CHCl3 (50 mL) and methyl 3-mercaptopropionate (9.2 mL) was added dropwise trimethylsilylchloride (6.5 mL). The reaction mixture was stirred 1 hour at room temperature, quenched with aqueous NH4OAc (25%), and extracted with ethyl acetate. Flash chromatography of the residue using 1:1 ethyl acetate/ hexane afforded the title compound.

Provenance & Evidence