HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → 2-(Bromomethyl)-5-chlorobenzo[d]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | 5-Chloro-2-methylbenzoxazole | HCID 29510 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 2-(Bromomethyl)-5-chlorobenzo[d]oxazole | HCID 12745945 | — |
Reaction Steps
A solution of the benzoxazole (1.3 g) (Step 2) in CCl4 (15 mL) was treated with N-bromo-succinimide (NBS) (1.5 g) and benzoyl peroxide (38 mg) at reflux using a U.V. lamp for 24 hours. Filtration, evaporation, and flash chromatography of the residue using 1:1 hexane/toluene afforded the title compound which was used as such for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04957932 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-c8a92444ed334775971a2479e214d719 |
| Source note | uspto-grants-1990_09 |