Water → HCID 22165605, compound

Participants

Reaction Steps

A solution of 3 g (7.78 mmole) of 1-[(phenylmethoxy)acetyl]-3-phenylpiperidine in 30 cm3 of tetrahydrofuran was added dropwise to a solution of 0.5 g (12.4 mmole) of lithium aluminum hydride in 50 cm3 of tetrahydrofuran. The mixture was heated to reflux for 4 hours, left overnight, and then hydrolyzed by the addition of 2.5 cm3 of water. It was diluted with 100 cm3 of ether. The alkaline sediments are separated and washed with ether. The ethereal phases were collected, dried on sodium sulfate and concentrated under reduced pressure. The residue was dissolved in 20 cm3 of acetone. A solution of 0.75 g (8.3 mmole) of oxalic acid in 30 cm3 of acetone was added. The oxalate precipitate was filtered, and recrystallized from acetone.

Provenance & Evidence