Sodium Hydroxide → HCID 22165516, compound

HRID 1032357Notes

Reaction equation

HRID 1032357 reaction equation
[OH-].[Na+].C([O:6][CH2:7][C:8](=[O:14])[CH2:9][O:10][C:11](=[O:13])[NH2:12])(=O)C>CO>[OH:6][CH2:7][C:8](=[O:14])[CH2:9][O:10][C:11](=[O:13])[NH2:12]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22165505HCID 22165505, compound

Product 1

HCID 22165516HCID 22165516, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Aqueous sodium hydroxide (35 ml. of a 2.5N solution) is added dropwise over 30 minutes to a stirred solution of 1-acetoxy-3-carbamoyloxy-2-propanone (14.9 g., 0.085 g.) in methanol (10 ml.). The methanol is evaporated under reduced pressure and the aqueous residue extracted with chloroform (3×25 ml.). The combined extracts are dried, and the solvent is removed in vacuo to afford 1-hydroxy-3-carbamoyloxy-2-propanone.

Workup

  1. customThe methanol is evaporated under reduced pressure
  2. extractionthe aqueous residue extracted with chloroform (3×25 ml.)
  3. customThe combined extracts are dried
  4. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-1b1b01131dd44973a4d21e3a323d592a
Source dataset
uspto-grants-1990_09
Patent number
US04957912

Reaction notes

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