Ethyl Bromide → HCID 14547437, compound

Participants

Reaction Steps

A solution of 4-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-butynoic acid (2.50 g), benzyltrimethylammonium hydroxide (0.87 g) and ethyl bromide (0.62 g) in dimethyl sulphoxide (5 ml) was stirred at room temperature for 48 hours, quenched into water and extracted twice into ethyl acetate. The combined ethyl acetate extracts were washed with water, dried over MgSO4 and evaporated. The residue was crystallised from methanol to give the title compound (2.22 g), m.p. 123°-125°.

Provenance & Evidence