Pyridinium chloride → HCID 10358396, compound

HRID 1032378Notes

Reaction equation

HRID 1032378 reaction equation
[CH:1]([C:4]1[C:12]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][CH:17]=2)(=[O:15])=[O:14])=[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][N:6]2[N:5]=1)([CH3:3])[CH3:2].Cl.N1C=CC=CC=1>O>[CH:1]([C:4]1[C:12]([S:13]([C:16]2[CH:17]=[CH:18][C:19]([OH:22])=[CH:20][CH:21]=2)(=[O:15])=[O:14])=[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][N:6]2[N:5]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 11724188Pyrazolo[1,5-a]pyridine, 3-[(4-methoxyphenyl)sulfonyl]-2-(1-methylethyl)-

Product 1

HCID 10358396HCID 10358396, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
220 °C

Procedure

A mixture of 0.012 mol of 2-isopropyl-3-(4-methoxybenzenesulphonyl) pyrazolo[1,5-a]pyridine and 0.054 mol of pyridine hydrochloride was heated at 220° C. for & hour. Water was then added and the mixture was distilled in the presence of ethyl acetate. The medium was dried on sodium sulphate, filtered and concentrated. The solid so obtained was then recrystallized from isopropyl ether to provide a white crystalline product.

Workup

  1. distillationthe mixture was distilled in the presence of ethyl acetate
  2. customThe medium was dried on sodium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe solid so obtained
  6. customwas then recrystallized from isopropyl ether
  7. customto provide a white crystalline product

Sources & evidence

ORD record
ord-61706da8b9ce43d2bf877090d3ee22c5
Source dataset
uspto-grants-1990_09
Patent number
US04957925

Reaction notes

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