Benzoyl Peroxide → 2-Bromo-2-(4-chlorophenoxy)-1-phenylethan-1-one

HRID 1032459Notes

Reaction equation

HRID 1032459 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:19]=[CH:18][C:7]([O:8][CH2:9][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])=[CH:6][CH:5]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)Cl>[Br:1][CH:9]([O:8][C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:19][CH:18]=1)[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:11]

Participants

5

Reactant 3

HCID 7187Benzoyl PeroxideHCID 24408BromineHCID 3095712-(4-Chlorophenoxy)-1-phenylethanone

Product 1

HCID 130629322-Bromo-2-(4-chlorophenoxy)-1-phenylethan-1-one

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

Bromine (11.6g) in chloroform (40ml) was added dropwise to a stirred solution of 4-chloro-α-phenoxyacetophenone (18.8g) in chloroform (1200ml) containing dibenzoyl peroxide (50 mg) under photoflood illumination. The reaction was complete after 2 hours, and the chloroform was removed under reduced pressure to give α-bromo-4-chloro-α-phenoxyacetophenone which was used without further purification.

Workup

  1. customthe chloroform was removed under reduced pressure

Sources & evidence

ORD record
ord-8b9856266e3e45779906c452b0035492
Source dataset
uspto-grants-1990_09
Patent number
US04957934

Reaction notes

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