tert-Butanol → HCID 54093447, compound

Participants

Reaction Steps

A mixture of 3-(4-chlorophenyl)1-(1,2,4-triazol-1-yl)butan-2-one (0.7g), trimethylsulphoxonium iodide (0.77g), potassium hydroxide (0.38g) and 1,2,4-triazole (0.24g) in tert butyl alcohol (lOml) was heated at reflux for 4h. The reaction mixture was cooled and poured into water, and the aqueous phase was separated and extracted with ethyl acetate. The organic extract was separated, dried and concentrated to dryness under reduced pressure, and the residue was purified by column chromatography on silica using 2% by volume methanol in chloroform as eluent, to give 3 (4 chlorophenyl)-1-(1,2,4-triazol-1-yl)-2(1,2,4-triazol-1-ylmethyl)butan-2-ol mp 60-64° .

Provenance & Evidence