Imidazole → HCID 22165707, compound

Participants

Reaction Steps

1-(4-trifluoromethylphenyl)-3-(1,2,4,-triazol-1-yl)propan-2-one (1.5 g), trimethylsulphoxonium iodide (1.5 g), imidazole (0.46 g), potassium carbonate (0.75 g) in tert-butyl alcohol (20 ml) was heated at φ° for 3 h. The reaction mixture was partitioned between ethyl acetate and water, and the organic layer was separated, washed with water and then brine, and dried. The dried extract was evaporated to dryness under reduced pressure, and the residue was purified by chromatography on silica, using 5% by volume methanol in chloroform as eluent. After evaporation of the solvent, the residue crystallised from a mixture of ethyl acetate and hexane to give 3-(imidazol-1-yl)1-(1,2,4-triazol-1-yl)-2(4-trifluoromethylbenzyl)-propan-2-ol, m.p. 154-155°C. (Example 30). In a similar manner there were prepared 2-(4-chlorobenzyl)-3-(imidazol-1yl)-1-(1,2,4-triazol-1-yl) propan-2-ol, m.p. 159-161° (Example 31) and 1,3-di(imidazol-1yl)-2-(4-trifluoromethylbenzyl)propan-2-ol, m.p. 177-178° (Example 32). ##STR1##

Provenance & Evidence