Ammonia → N-benzyl-5,6-dihydroxyisoindoline

HRID 1032486Notes

Reaction equation

HRID 1032486 reaction equation
Br.[CH2:2]([N:9]1[CH2:17][C:16]2[C:11](=[CH:12][C:13]([OH:19])=[C:14]([OH:18])[CH:15]=2)[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.N>CO>[CH2:2]([N:9]1[CH2:10][C:11]2[C:16](=[CH:15][C:14]([OH:18])=[C:13]([OH:19])[CH:12]=2)[CH2:17]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20074353HCID 20074353, compound

Product 1

HCID 14993738N-benzyl-5,6-dihydroxyisoindoline

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.0 g (3.1 mmol) of N-benzyl-5,6-dihydroxyisoindoline hydrobromide was dissolved in 40 ml of a 50% methanol aqueous solution, and the solution was adjusted to pH 8.0 with 8% aqueous ammonia. The precipitated crystals were collected by filtration and washed with 5 ml of cold water and 5 ml of cold acetone to obtain 640 mg of the above identified compound.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with 5 ml of cold water and 5 ml of cold acetone
  3. customto obtain 640 mg of the

Sources & evidence

ORD record
ord-1edfc9d200314d5dbbbe054d5acaa62a
Source dataset
uspto-grants-1990_09
Patent number
US04958029

Reaction notes

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