反应详情

温度

25 °C

To a stirred mixture of 6.01 g of 4-(2-furyl)-1-butyne [Perfumery Essent. Oil Record., 57, 364 (1966)], 10.6 g of sodium carbonate and 150 ml of methanol at -25° C., was added dropwise a solution of 8.0 g of bromine in 50 ml of methanol during a period of 3 hours. The mixture was then stirred at 25° C. for 45 minutes and concentrated in vacuo. The residue was partitioned with ether and brine. The ether layer was separated, washed with brine, dried and concentrated. Distillation of the residue at 0.5mm gave 6.62 g of the desired compound as a light yellow liquid, bp 57°-61° C. (0.5 mm).

1. concentrationconcentrated in vacuo
2. customThe residue was partitioned with ether and brine
3. customThe ether layer was separated
4. washwashed with brine
5. customdried
6. concentrationconcentrated
7. distillationDistillation of the residue at 0.5mm