反应详情

In the presence of Raney nickel, 36.0 g of 2-(4-benzyloxy-3-nitrophenyl)acetic acid dipropylamide is hydrogenated in 600 ml of methanol until 6.7 l of hydrogen has been absorbed, which takes about 4.5 hours. The crude product obtained after removing the catalyst by filtration and after evaporation is chromatographed on silica gel with cyclohexane/ethyl acetate (1:1), thus obtaining 24.4 g of pure 2-(3-amino-4-benzyloxyphenyl)acetic acid dipropylamide as an oil.

1. customhas been absorbed
2. customThe crude product obtained
3. customafter removing the catalyst
4. filtrationby filtration
5. customafter evaporation
6. customis chromatographed on silica gel with cyclohexane/ethyl acetate (1:1)