1,3-Diethyl 2-oxopropanedioate → HCID 54166445, compound

Participants

Reaction Steps

2.5 g of N-[2-(4-amino-3-methoxyphenyl)ethyl]trifluoroacetamide and 1.9 ml of mesoxalic acid diethyl ester are dissolved in 25 ml of acetic acid and refluxed for 4 hours. The mixture is concentrated, the residue dissolved in ethyl acetate and extracted twice by shaking with saturated sodium bicarbonate solution. The mixture is concentrated and chromatographed on silica gel with cyclohexane/ethyl acetate 1:1, thus obtaining 2.5 g of 2,3-dihydro-3-hydroxy-7-methoxy-2-oxo-5-(trifluoroacetamidoethyl)-3-indolecarboxylic acid ethyl ester, mp 115°-117° C.

Provenance & Evidence