Formic Acid → HCID 22166007, compound

Participants

Reaction Steps

Under ice cooling, 4 ml of a mixture of formic acid and acetic anhydride (ratio 3:5) is added dropwise to 3.2 g of 2-(benzyloxy-5-(2-dipropylaminoethyl)aniline in 10 ml of chloroform, then the mixture is stirred for 2 hours at room temperature. The solution is washed with aqueous NaHCO3 solution, concentrated, and the residue chromatographed on silica gel with methylene chloride/acetone (1:1), yielding 1.8 g of N-[2-benzyloxy-5-(2-dipropylaminoethyl)phenyl]formamide as an oil.

Provenance & Evidence