Tetrahydrofuran → HCID 131716573, compound

Participants

Reaction Steps

600 mg of N,N-dipropyl-N- 2-(7-nitro-1H-indazol-4-yl)ethyl amine, hydrochloride, in 10 ml of methanol and 10 ml of tetrahydrofuran is hydrogenated in the presence of 0.5 g of Raney nickel. The mixture is filtered off from the catalyst, combined with ethereal hydrochloric acid, and concentrated. The residue is recrystallized from methanol/diethyl ether, yielding 360 mg of N,N-dipropyl-N- 2-(7-amino-1H-indazol-4-yl)ethyl amine, dihydrochloride, mp 214°-218° C.

Provenance & Evidence