Hydrogen Bromide → HCID 178419551, compound

Participants

Reaction Steps

Under argon, 480 mg of N,N-dipropyl-N-[2-(3-hydroxy-7-methoxy-1H-indazol-4-yl)ethyl]amine, hydrochloride, is heated to 120° C. in 5 ml of aqueous hydrogen bromide (65%) for 4 hours. The mixture is concentrated and once distilled with water. The residue is dried, triturated with diethyl ether, and repeatedly recrystallized from ethanol/acetone/diethyl ether, thus obtaining 340 mg of N-[2-(3,7-dihydroxy-1H-indazol-4-yl)ethyl]-N,N-dipropylamine, hydrobromide, decomposition point 242°-244° C.

Provenance & Evidence