Formic Acid → HCID 178457196, compound

Participants

Reaction Steps

1.2 g of N-[2-(2,3-diamino-4-methoxyphenyl)ethyl]-N,N-dipropylamine is heated under reflux with 20 ml of formic acid for 3 hours. The solution is concentrated. The residue is taken up in water, made alkaline with potassium carbonate, and extracted with ethyl acetate. The organic phase is dried over sodium sulfate and concentrated after the drying agent has been removed by filtration. The residue is chromatographed on silica gel with a mixture of dichloromethane/methanol, thus obtaining 0.42 g of 7-methoxy-4-[2-(N,N-dipropylamino)ethyl]benzimidazole as an oil.

Provenance & Evidence