Acetic Acid → HCID 178490305, compound

HRID 1032552Notes

Reaction equation

HRID 1032552 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][N:13]([CH3:15])[CH3:14].[C:16](O)(=O)[CH3:17]>>[CH3:10][O:9][C:6]1[C:7]2[N:8]=[C:16]([CH3:17])[NH:1][C:2]=2[C:3]([CH2:11][CH2:12][N:13]([CH3:15])[CH3:14])=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 13771317HCID 13771317, compound

Product 1

HCID 178490305HCID 178490305, compound

Procedure

0.6 g of N-[2-(2,3-diamino-4-methoxyphenyl)ethyl]-N,N-dimethylamine is heated under reflux with 10 ml of acetic acid for 3 hours. The reaction mixture is concentrated, taken up in ethyl acetate, and extracted by shaking with sodium bicarbonate solution. The organic phase is separated, dried with sodium sulfate, and concentrated, thus obtaining 286 mg of 7-methoxy-4-[2-(N,N-dimethylamino)ethyl]-2-methylbenzimidazole as an oil.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. extractionextracted
  3. customThe organic phase is separated
  4. dry with materialdried with sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-cf05d731026b4b41a3ff8c6a51e0bd6f
Source dataset
uspto-grants-1990_09
Patent number
US04958026

Reaction notes

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