Tetrahydrofuran → HCID 13771339, compound

Participants

Reaction Steps

500 mg of N-[2-(2,3-diamino-4-methoxyphenyl)ethyl]-N,N-dimethylamine is heated under reflux for 3 hours with 40 ml of tetrahydrofuran and 500 mg of N,N'-carbonyldiimidazole. After concentration, the residue is combined with methanol and water. The mixture is again concentrated and dried over phosphorus pentoxide, thus obtaining 410 mg of 7-methoxy-4-[2-(N,N-dimethylamino)ethyl]-2,3-dihydro-2-benzimidazolone, mp 197°-199° C.

Provenance & Evidence