Methanol → HCID 131716545, compound

Participants

Reaction Steps

To a suspension comprising 30 g of 7-amino-3-[(2-methoxy- methyl-5-methyl-s-triazolo[1,5-a]pyrimidin-7-yl)thio -methyl]-3-cephem-4-carboxylic acid, 170 ml of methanol and 510 ml of methylene chloride was added dropwise while stirring diphenyldiazomethane, which had been synthesized from 39.25 g of benzophenonehydrazone, 43.22 g of mercuric oxide (yellow) and 350 ml of n-hexane, in 50 ml of methylene chloride, and the mixture was stirred at room temperature overnight. After the reaction mixture was condensed and ether was added thereto to effect crystallization. The crystals were collected by filtration and dried, and the resulting powder was purified through silica gel column chromatography to obtain 31.1 g of the title compound.

Provenance & Evidence