참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | HCID 178498586 | HCID 178498586 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | HCID 178498584 | HCID 178498584 | — |
반응 단계
A mixture of 25.7 g of 7-hydroxy-2-hydroxymethyl-5-methoxycarbonyl-s-triazolo[1,5-a]pyrimidine, 200 of DMF, 47 ml of acetic anhydride and 1 g of p-toluenesulfonic acid was stirred at 60° C. for 24 hours. The reaction mixture was condensed and 100 ml of methanol was added to the crystals precipitated residue, and the mixture was stirred. Then, crystals were collected by filtration, washed with methanol and dried to obtain 8.9 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04958019 |
|---|
| 출처 데이터셋 | uspto-grants-1990_09 |
|---|
| ORD ID | ord-6ec77b0207f6434da0834788576b5971 |
|---|
| 출처 메모 | uspto-grants-1990_09 |
|---|
