反应详情

In 300 ml of ethanol was dissolved 14 g of 7-chloro-2,5-bis(acetoxymethyl)-s-triazolo[1,5-a]pyrimidine, and 10.7 g of thiourea was added thereto and the mixture was refluxed for 10 minutes. After removing ethanol from the reaction mixture, the residue was dissolved in 230 ml of a 5 % potassium hydroxide. The mixture was stirred for 30 minutes, ice-cooled and adjusted to pH 2 with 2N hydrochloric acid. Precipitated crystal was collected by filtration, washed with water and dried to obtain 7.16 g of the title compound.

1. additionwas added
2. temperaturethe mixture was refluxed for 10 minutes
3. customAfter removing ethanol from the reaction mixture
4. dissolutionthe residue was dissolved in 230 ml of a 5 % potassium hydroxide
5. temperatureice-cooled
6. customPrecipitated crystal
7. filtrationwas collected by filtration
8. washwashed with water
9. customdried