Dimethylformamide → HCID 14998282, compound

Participants

Reaction Steps

2.2 g of 2-[2-(2,3-dihydro-2,2-dimethyl-5-benzofuranyl)ethoxy]-5-aminopyridine was dissolved into 10 ml of N,N-dimethylformamide, and 0.9 g of triethylamine was added thereto. 1.2 g of N-methoxy-N-methylcarbamoyl chloride was slowly added dropwise thereto. After the mixture was stirred at room temperature, the reaction mixture was poured into water and extracted with ethyl acetate. After the organic layer was washed with water, it was dried over anhydrous magnesium sulfate and ethyl acetate was dried off. The residue was subjected to silica gel column chromatography using ethyl acetate/n-hexane (2/3) as a developer to obtain 2.1 g of 1-{2-[2-(2,3-dihydro-2,2-dimethyl-5-benzofuranyl)ethyloxy]-5-pyridyl}-3-methoxy-3-methylurea.

Provenance & Evidence