S-(2-Oxo-1-phenylpropyl) ethanethioate → HCID 13027653, compound

Participants

Reaction Steps

Under nitrogen a mixture of 10.6 g (0.05 mol) of ethanethioic acid S-(2-oxo-1-phenylpropyl)ester and 130 ml of 5% sodium hydroxide was stirred rapidly at room temperature for 45 minutes, then extracted with ether. The aqueous mixture was chilled in an ice-bath, acidified with 6N HCl and extracted with ether. The combined organic extracts were washed with brine, dried (MgSO4) and the solvent was removed to give 6.9 g (82%) of crude rac.-1-mercapto-1-phenyl-2-propanone. This compound is sensitive to air and therefore the crude product was used immediately for the condensation reaction.

Provenance & Evidence