Hydrochloric Acid → HCID 13882782, compound

Participants

Reaction Steps

To a solution of 2-O-octadecyl-L-ascorbic acid (0.8 g, 2 mmole) in chloroform (20 ml) was added pyridine (1 ml), followed by adding dropwise benzoyl chloride (0.28 g, 2 mmole) at room temperature. The reaction mixture was stirred for one hour, to which was added 2N hydrochloric acid to acidify it. The organic layer was washed with water and dried (over magnesium sulfate). The solvent was evaporated off, and the product was recrystallized from isopropyl ether-ethyl acetate to give 3-O-benzoyl-2-O-octadecyl-L-ascorbic acid (0.6 g, 49%), m.p. 68°-69° C. C3H48O7 (Found: C,69.94; H,8.98%. Anal. Calcd: C,69.89; H,9.08)

Provenance & Evidence