HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-(2-Chloroethoxy)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Hydroxybenzamide | HCID 65052 | — |
| Reactant | 2-Chloroethyl Benzenesulfonate | HCID 13634485 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 4-(2-Chloroethoxy)benzamide | HCID 13569171 | — |
Reaction Steps
A mixture of 4-hydroxybenzamide (194 g, 1.25M), 2-(benzenesulphonyloxy)ethyl chloride (359 g, 1.8M), and potassium carbonate (172.8 g, 1.25M) in butan-2-one (2.16 1) was stirred at reflux for 24 hours. After cooling, distilled water (2.0 1) was added and the resultant precipitate filtered off, washed with water, and dried. Crystallisation from ethanol gave the title compound, yield (232.0 g), m.p. 66°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04959366 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-5a6182fcaddf40e0a3bba976ba19cbe9 |
| Source note | uspto-grants-1990_09 |