HCID 14403357, compound → HCID 14403385, compound

Participants

Reaction Steps

78.0 g (0.21 mole) of 3-(4-acetaminobenzoyl)-7-benzyl-3,7-diazabicyclo[3.3.1]nonane (cf. Example 1) were dissolved in 1.3 l of methanol, and 3.0 g of 10% strength palladium/carbon were added. Hydrogenation was carried out until an equimolar amount of hydrogen had been consumed. The reaction mixture was filtered and the filtrate was evaporated down under reduced pressure. Crystalline 3-(4-acetaminobenzoyl)-3,7-diazabicyclo[3.3.1]nonane was obtained. Yield: 59 g, mp.: 186°-189° C.

Provenance & Evidence