反应详情

A mixture composed of 20 g (56.1 mmoles) of ethyl 2-(4-benzylpiperazino)-4-hydroxypyrimidine-5-acetate (prepared in accordance with Referential Example 70 of Japanese Laid-Open Patent Publication No. 140568/1986), 7.5 g (114 moles) of 85% KOH tablets and 320 ml of ethanol was refluxed for 1 hour. The reaction mixture was concentrated to a solid. Hydrochloric acid and saturated aqueous sodium bicarbonate solution were added to adjust the pH to 4, and the mixture was again concentrated. The resulting crude crystals were recrystallized from water to give 17 g (yield 92%) of 2-(4-benzylpiperazino)-4-hydroxypyrimidine-5-acetic acid as a colorless solid.

1. customprepared in accordance with Referential Example 70 of Japanese Laid-Open Patent Publication No
2. concentrationThe reaction mixture was concentrated to a solid
3. additionHydrochloric acid and saturated aqueous sodium bicarbonate solution were added
4. concentrationthe mixture was again concentrated
5. customThe resulting crude crystals were recrystallized from water