Triethylamine → HCID 22164882, compound

Participants

Reaction Steps

A mixture of 3 dimethylaminopiperidine dihydrochloride (0 9 g, 0.005 mol), triethylamine (1.5 g, 0.015 mol) and dichloromethane (20 ml) was stirred for 15 min. 3,5-Dichlorobenzoylchloride (1.05 g, 0.005 mol) was then added and stirring continued for a further 2 h. The solution was then washed with aqueous sodium carbonate solution, dried and evaporated. The residue was dissolved in isopropyl alcohol (15 ml) and acidified with ethanolic hydrogen chloride to precipitate the crystalline hydrochloride 1.3 g, mp 242-244° C.

Provenance & Evidence