反应详情

2-[2-[(6-Bromohexyl)oxy]ethyl]pyridine (6.3 g) was added to benzylamine (20 ml) at 140° under nitrogen. After 1 h at 140° the reaction mixture was cooled and partitioned between 2M sodium hydroxide (100 ml) and ether (100 ml). The organic layer was washed with water and brine, dried and concentrated to a yellow oil. The excess benzylamine was removed by distillation under reduced pressure to leave the title compound as a yellow oil (6.8 g), t.l.c. (toluene-ethanol-0.88 ammonia 80:20:2) Rf 0.44.

1. temperatureAfter 1 h at 140° the reaction mixture was cooled
2. custompartitioned between 2M sodium hydroxide (100 ml) and ether (100 ml)
3. washThe organic layer was washed with water and brine
4. customdried
5. concentrationconcentrated to a yellow oil
6. customThe excess benzylamine was removed by distillation under reduced pressure