Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-(4-Fluorophenyl)-4-oxo-7-(4-pyridyl)quinoline-3-carboxamide | HCID 443370 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Morpholinium, 4-methylene-, chloride | HCID 11367014 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 492949 | HCID 492949 | 65.3% |
Reaction Steps
A mixture of 1.08 g 1-(4-fluorophenyl)-1,4-di -hydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxamide (Example 1 h), 0.45 g N-methylenemorpholinium chloride and 10 ml DMF was heated at 100° C. for 15 min. The reaction mixture was cooled, poured into 100 ml water and the pH adjusted to 8 with saturated sodium bicarbonate solution. The solid precipitate was collected, dried and recrystallized from an acetonitrile -chloroform mixture to give 0.90 g N-(4-morpholinylmethyl)-1-(4-fluorophenyl)1,4 -dihydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxamide, m.p. 258-260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04959363 |
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| Source dataset | uspto-grants-1990_09 |
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| ORD ID | ord-d4796169f85e4e5fb59f8bb67dfcf2ea |
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| Source note | uspto-grants-1990_09 |
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