3,4-Dichloroaniline → HCID 478692, compound

HRID 1032720Notes

Reaction equation

HRID 1032720 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]4[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=4)[CH:17]=3)[C:12](=[O:25])[C:11]([C:26]([O:28]CC)=O)=[CH:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].ClC1C=C(C=CC=1Cl)[NH2:35].FC1C=CC(N)=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]4[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=4)[CH:17]=3)[C:12](=[O:25])[C:11]([C:26]([NH2:35])=[O:28])=[CH:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 3

HCID 72573,4-DichloroanilineHCID 97314-FluoroanilineHCID 9980597HCID 9980597, compound

Product 1

HCID 478692HCID 478692, compound

Procedure

The starting acid was prepared by hydrolysis of ethyl 1-(3,4-dichlorophenyl)-1,4-dihydro-4-oxo-7-(4- pyridinyl)-3-quinolinecarboxylate (tan solid, m.p. 238°-240 ° C. when recrystallized from toluene), in turn prepared according to the procedures of Example 1, parts (e) and (f), substituting 3,4-dichloroaniline for the 4-fluoroaniline of part (e).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-8a711a27676f481eb12094b3f63e8b93
Source dataset
uspto-grants-1990_09
Patent number
US04959363

Reaction notes

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