Lithium → HCID 10063713, compound

HRID 1032723Notes

Reaction equation

HRID 1032723 reaction equation
[Li].[C:2]([O:8][CH2:9][CH3:10])(=[O:7])[CH2:3][C:4]([O-:6])=O.[Br:11][C:12]1[CH:20]=[CH:19][C:15](C(Cl)=O)=[C:14]([Cl:21])[CH:13]=1>>[Br:11][C:12]1[CH:20]=[CH:19][C:15]([C:4]([CH2:3][C:2]([O:8][CH2:9][CH3:10])=[O:7])=[O:6])=[C:14]([Cl:21])[CH:13]=1

Participants

4

Reactant 3

HCID 3028194LithiumHCID 3595298Propanedioic acid, monoethyl esterHCID 155922074-Bromo-2-chlorobenzoyl chloride

Product 1

HCID 10063713HCID 10063713, compound

Procedure

The starting material was prepared by conventional procedures starting from the lithium salt of monoethyl malonate and 4-bromo-2-chlorobenzoyl chloride which reacted to form ethyl 4-bromo-2-chlorobenzoylacetate. The latter was caused to react with dimethylformamide dimethylacetal to give ethyl 3-dimethylamino-2-(4-bromo2-chlorobenzoyl)propenoate, which by reaction with 4-fluoroaniline afforded said starting material.

Workup

  1. customThe starting material was prepared by conventional procedures
  2. customreacted

Sources & evidence

ORD record
ord-2734a6d132c34ca48c11bdd887217525
Source dataset
uspto-grants-1990_09
Patent number
US04959363

Reaction notes

Loading…