Potassium Fluoride → HCID 10472113, compound

Participants

Reaction Steps

A mixture of 23.3 g ethyl 1,4-dihydro-1-(4-fluorophenyl)-4-oxo-7-(trimethylsilylethynyl)-3-quinolinecarboxylate, 10.5 g potassium fluoride and 700 ml ethanol was heated at reflux for 4 hrs. The reaction mixture was concentrated in vacuo and the residue triturated with chloroform. The chloroform-soluble fraction was isolated and recrystallized from ethyl acetate to give 14.02 g ethyl 1,4-dihydro-7-ethynyl-1-(4-fluorophenyl)-4-oxo-3quinolinecarboxylate, m.p. 227°-229° C. d) 1,4-dihydro-1-(4-fluorophenyl)-7-(3-methyl-5

Provenance & Evidence