Nitroethane → HCID 10453105, compound

Participants

Reaction Steps

A solution of 9.8 g nitroethane and 13 ml triethylamine in 130 ml chloroform was added dropwise to a solution of 10.47 g ethyl 1,4-dihydro-7-ethynyl-1-(4- fluorophenyl)-4-oxo-3-quinolinecarboxylate and 15.5 g phenyl isocyanate in 80 ml chloroform over a period ofconcentrated in vacuo. The residue was crystallized in ether and recrystallized from acetonitrile to give 8.60 g ethyl 1,4-dihydro-1-(4-fluorophenyl)-7-(3-methyl-5-isoxazolyl)4 -oxo-3-quinolinecarboxylate (yellow solid, m.p. 214°-216° C.).

Provenance & Evidence