HCID 10315575, compound → HCID 22164813, compound

Participants

Reaction Steps

A mixture of 4.34 g ethyl 7-chloro-1,4-dihydro1-(4-fluorophenyl)-4-oxo-3-quinolinecarboxylate, 6.55 g 3-methyl-5-trimethylstannylthiazole and 1.52 g dichloro- bis-triphenylphosphine palladium in 150 ml absolute ethanol was heated at 150° C. in a stirred stainless steel bomb for about 16 hrs. The product was isolated and chromatographed on silica gel. Elution with 1:1 ethyl acetate/hexane and 100% ethyl acetate gave 2.67 g ethyl 1,4-dihydro-1-(4-fluorophenyl)-7-(3-methyl-5-thiazolyl)-4- oxo-3-quinolinecarboxylate as a yellow solid.

Provenance & Evidence