1-Ethyl-7-isoxazol-5-yl-4-oxo-quinoline-3-carboxamide → 1-(4-Fluorophenyl)-4-oxo-7-phenyl-quinoline-3-carboxamide

Participants

Reaction Steps

1,4-Dihydro-1-(4-fluorophenyl)-4-oxo-7-phenyl-3-quinolinecarboxamide [I; R=H, R1 =4-FC6H4, R2 =H, R6 =H, R7C6H5 ] was prepared from 2.22 g 1,4-dihydro-7-chloro1-(4-fluorophenyl)-4-oxo-3-quinolinecarboxamide (Example 42c), 3.30 g tributylstannylbenzene (prepared from tributyltin chloride and bromobenzene) and 2.50 g dichlorobis-triphenylphosphine palladium according to the procedure of Example 37, part (c), and was obtained (1.4 g) as colorless crystals, m.p. 289-292° C. when recrystallized from acetonitrile.

Provenance & Evidence