HCID 14851835, compound → HCID 14851847, compound

HRID 1032754Notes

Reaction equation

HRID 1032754 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16](I)[CH:17]=[CH:18][C:13]=2[N:12]2[C:20]([CH3:23])=[N:21][N:22]=[C:11]2[CH2:10][N:9]=1.[CH3:24][C:25]1[N:34]([CH2:35][C:36]#[CH:37])[C:33](=[O:38])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:26]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:37]#[C:36][CH2:35][N:34]3[C:33](=[O:38])[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[N:26]=[C:25]3[CH3:24])[CH:17]=[CH:18][C:13]=2[N:12]2[C:20]([CH3:23])=[N:21][N:22]=[C:11]2[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 14851835HCID 14851835, compoundHCID 14911063HCID 14911063, compound

Product 1

HCID 14851847HCID 14851847, compoundYield 57%

Procedure

This compound was obtained by coupling 6-(2-fluorophenyl)-8-iodo-1-methyl-4H-[1,2,-4]triazolo[4,3-a][1,4]benzodiazepine with 2-methyl-3-(2-propynyl)-4(3H)-quinazolinone [ref. B. Danielsson, L. Kronberg and B. Akerman, Acta Pharm. Suecica, 6, 379, (1969)] as described in ex. 17. It was isolated in 57% yield and crystallized from ethyl acetate. m.p. 241°-244° C. with decomposition. The crystals contained 0.66 molar amounts of water.

Workup

  1. customThis compound was obtained
  2. customIt was isolated in 57% yield
  3. customcrystallized from ethyl acetate

Sources & evidence

ORD record
ord-1b33c96da832436e8dfe8f6543a8d4cf
Source dataset
uspto-grants-1990_09
Patent number
US04959361

Reaction notes

Loading…