Acetylene → HCID 14851849, compound

Participants

Reaction Steps

This compound was obtained as described in example 17 by coupling of 6-(2-fluorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine with 2-(2-propynyl)-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one. The product was purified by chromatography in the usual fashion and crystallized from ethyl acetate/ethanol. Recrystallization from ethanol gave light yellow crystals with m.p. 170°-173° C. They contained 0.66 molar amounts of water. The synthesis of the required acetylene is described in Example 27.

Provenance & Evidence