HCID 12244397, compound → HCID 14851850, compound

HRID 1032757Notes

Reaction equation

HRID 1032757 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16](I)[CH:17]=[CH:18][C:13]=2[N:12]2[C:20]([CH3:23])=[N:21][N:22]=[C:11]2[CH2:10][N:9]=1.[CH2:24]([N:27]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[N:28]1)[C:25]#[CH:26]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:26]#[C:25][CH2:24][N:27]3[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH:29]=[N:28]3)[CH:17]=[CH:18][C:13]=2[N:12]2[C:20]([CH3:23])=[N:21][N:22]=[C:11]2[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 12244397HCID 12244397, compoundHCID 14851835HCID 14851835, compound

Product 1

HCID 14851850HCID 14851850, compound

Procedure

This compound was obtained as described in example 17 by reaction of 6-(2-fluorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine with 1-(2-propynyl) 1H-indazole [ref. p. V. Tkachenko, I. I. popov, A. M. Simonov and Yu. V. Medvedov, Khim. Geterotsikl. Soedin. 11, 1542 (1975)]. The chromatographically isolated product was crystallized from ethyl acetate to give yellowish crystals with m.p. 148°-151° C.

Workup

  1. customThis compound was obtained
  2. customThe chromatographically isolated product was crystallized from ethyl acetate
  3. customto give yellowish crystals with m.p. 148°-151° C.

Sources & evidence

ORD record
ord-923fed53aaa1456aaf04a091fd14b2bc
Source dataset
uspto-grants-1990_09
Patent number
US04959361

Reaction notes

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