HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Prop-2-ynyloxy)benzene → 6-(2-Chlorophenyl)-1-methyl-8-(3-phenoxy-1-propynyl)-4H-[1,2,4]triazolo [4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Prop-2-ynyloxy)benzene | HCID 83613 | — |
| Reactant | 6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine | HCID 14851894 | — |
| Product | 6-(2-Chlorophenyl)-1-methyl-8-(3-phenoxy-1-propynyl)-4H-[1,2,4]triazolo [4,3-a][1,4]benzodiazepine | HCID 14851857 | — |
Reaction Steps
This compound was obtained by coupling 6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine with 1-phenoxy-2-propyne as described in example 1. Chromatographic isolation and crystallization from ethyl acetate gave colorless crystals with m.p. 160°-162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04959361 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-5ca170243ac5446da0246f79c4db3920 |
| Source note | uspto-grants-1990_09 |