2-(2-Propynyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide → HCID 14851864, compound

HRID 1032762Notes

Reaction equation

HRID 1032762 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16](I)[S:17][C:13]=2[N:12]2[C:19]([CH3:22])=[N:20][N:21]=[C:11]2[CH2:10][N:9]=1.[CH2:23]([N:26]1[C:30](=[O:31])[C:29]2[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=2[S:27]1(=[O:37])=[O:36])[C:24]#[CH:25]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:25]#[C:24][CH2:23][N:26]3[C:30](=[O:31])[C:29]4[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=4[S:27]3(=[O:37])=[O:36])[S:17][C:13]=2[N:12]2[C:19]([CH3:22])=[N:20][N:21]=[C:11]2[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 3909292-(2-Propynyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxideHCID 148519244-(2-chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

Product 1

HCID 14851864HCID 14851864, compound

Procedure

The title compound was prepared by reacting 4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazol[4,3-a][1,4]diazepine with 2-(2-propynyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide [ref. R. Granger and J. Giroux, French patent No. 1,273,867 February 1962] as described in Example 37. It was isolated by chromatography and crystallized from ethyl acetate to give colorless crystals with m.p. 232°-234° C.

Workup

  1. customIt was isolated by chromatography
  2. customcrystallized from ethyl acetate
  3. customto give colorless crystals with m.p. 232°-234° C.

Sources & evidence

ORD record
ord-e0b849a57cf741f596ddbed042daffc4
Source dataset
uspto-grants-1990_09
Patent number
US04959361

Reaction notes

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