HCID 14851960, compound → 6(5H)-Phenanthridinone

HRID 1032784Notes

Reaction equation

HRID 1032784 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[C:11]([C:12](=[O:19])[N:13](CC#C)[C:14]=2[CH:15]=1)=[CH:10][C:9](Cl)=[CH:8][CH:7]=3>O1CCCC1.CCCCCC>[CH:4]1[C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:12](=[O:19])[NH:13][C:14]=2[CH:15]=[CH:2][CH:3]=1

Participants

3

Reactant 1

HCID 14851960HCID 14851960, compound

Product 1

HCID 18536(5H)-Phenanthridinone

Reagents, catalysts & solvents 1

HCID 21883165Tetrahydrofuran hexaneSolvent

Procedure

The title compound was prepared by reacting 4-(2-chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f]1,2,4]triazolo[4,3-a][1,4]diazepine with 3.8-dichloro 5-(2-propynyl)-6(5H)-phenanthridinone under the conditions used in Example 37, but at the end, the reaction mixture was heated for minutes at 90°-95°. The product was isolated by chromatography over the 50-fold amount of silica gel using tetrahydrofuran/hexane 4:1 for elution. Crystallization of the combined clean fractions from tetrahydrofuran/ethyl acetate gave colorless crystals of 3,8-dichloro-5-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]1,4]diazepin-2-yl]-2-propynyl}-6(5H)-phenanthridinone with m.p. 218°-220°.

Workup

  1. temperatureat the end, the reaction mixture was heated for minutes at 90°-95°
  2. customThe product was isolated by chromatography over the 50-fold amount of silica gel
  3. washfor elution
  4. customCrystallization of the combined clean fractions from tetrahydrofuran/ethyl acetate

Sources & evidence

ORD record
ord-16dbb45c6a384799a429f4404e120713
Source dataset
uspto-grants-1990_09
Patent number
US04959361

Reaction notes

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